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Patients on dexamethasone may experience fewer overall side effects due to its relative lack of mineralocorticosteroid effects and consequently lower sodium retention than seen with other steroids. The most common side effects of dexamethasone include gastrointestinal effects, such as stomach cramps, nausea, vomiting, and diarrhea (2). Other uncommon side effects of dexamethasone include peripheral vascular complications and transient increases in blood pressure. Side effects may also progress over the course of treatment with dexamethasone. For example, some patients may need to stop treatment due to the development of severe or permanent renal impairment (3). Dexamethasone is a relatively new addition to the treatment of men seeking prostate cancer, but the drug has a well documented, long-term safety profile. The use of oral steroid hormones for other cancers has produced mixed results with many studies reporting benefits when steroids are used as recommended. However, there is a growing body of clinical data demonstrating that dexamethasone has an especially high rate of mortality when given to patients with advanced prostate cancer (4). Clinical Studies: DEXAMETHASONE® (dexamethasone hydrochloride) has been studied widely in over a quarter billion men and has accumulated more than 250 clinical studies. These studies have determined that dexamethasone significantly reduces the odds of clinically detectable prostate cancer. Related Article: